Background and purpose: One of the key indicators in discussions about air quality is the concentration of PM2. 5 particulate matter. This research employs a combined model that utilizes the maximum overlap discrete wavelet transform, Variational mode decomposition, and backpropagation neural network (MODWT-(VMD)-BPNN). This two-stage decomposition technique aims to predict PM2. 5 levels in the city of Urmia. Material and Methods: Data on air quality in Urmia City, including levels of particulate matter (PM10 and PM2. 5), carbon dioxide (CO2), sulfur dioxide (SO2), nitrogen dioxide (NO2), and nitrogen monoxide (NO), were obtained from the General Directorate of Environmental Protection for the years 2019 to 2023. Meteorological data were sourced from the General Directorate of Meteorology of West Azerbaijan Province. In the first stage of the analysis, the original PM2. 5 data series was decomposed into two high-frequency detail levels (d1 and d2) and one low-frequency approximation level (a2) using the Maximum Overlap Discrete Wavelet Transform (MODWT) model. In the second stage, each of these detail and approximation levels was further decomposed into eight variable modes using the Variable mode decomposition ((VMD)) model. Subsequently, each variable mode was simulated and predicted using a backpropagation neural network (BPNN). To evaluate the accuracy and performance of the proposed model, it was compared with the MODWT-BPNN, (VMD)-BPNN, and standard BPNN models. Results: After reviewing the results, the MODWT-(VMD)-BPNN model achieved R=0. 92, RMSE=3. 8074, and MAE=2. 8582 during training, and R=0. 80, RMSE=2. 7679, and MAE=2. 1840 during testing, demonstrating superior accuracy and performance compared to the other models. Conclusion: The two-stage decomposition models tackle mode mixing effectively and enhance the extraction and prediction of multiple frequencies in PM2. 5 data with greater precision. Open Access Policy: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this licence, visit https: //creativecommons. org/licenses/by/4. 0/